R33T (p.Arg33Thr) variant of CDK12 (Cyclin-dependent kinase 12)
R33T (p.Arg33Thr) in CDK12 (Cyclin-dependent kinase 12) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, published literature, and structural context.
R33T (p.Arg33Thr) variant details
- p.Arg33Thr
- gnomAD 17-39462169-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.428
- REVEL 0.24
- CADD 26.80
- PolyPhen-2 0.94
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available