R33K (p.Arg33Lys) variant of CDK12 (Cyclin-dependent kinase 12)
R33K (p.Arg33Lys) in CDK12 (Cyclin-dependent kinase 12) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
R33K (p.Arg33Lys) variant details
- p.Arg33Lys
- rs796501956
- NCI-TCGA Cosmic COSV7100
- cosmic curated COSV71002
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.338
- REVEL 0.12
- CADD 23.50
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available