R33G (p.Arg33Gly) variant of CDK12 (Cyclin-dependent kinase 12)
R33G (p.Arg33Gly) in CDK12 (Cyclin-dependent kinase 12) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
R33G (p.Arg33Gly) variant details
- p.Arg33Gly
- gnomAD rs1253774629
- Missense
- Variant Prioritization Score for Impact Estimate 0.434
- REVEL 0.28
- CADD 24.70
- PolyPhen-2 0.94
- SIFT 0.15
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available