P23R (p.Pro23Arg) variant of CDK12 (Cyclin-dependent kinase 12)
P23R (p.Pro23Arg) in CDK12 (Cyclin-dependent kinase 12) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data, published literature, and structural context.
P23R (p.Pro23Arg) variant details
- p.Pro23Arg
- gnomAD 17-39462139-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.337
- REVEL 0.13
- CADD 26.10
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available