M53T (p.Met53Thr) variant of CDK12 (Cyclin-dependent kinase 12)
M53T (p.Met53Thr) in CDK12 (Cyclin-dependent kinase 12) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data, published literature, and structural context.
M53T (p.Met53Thr) variant details
- p.Met53Thr
- gnomAD 17-39462229-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.139
- REVEL 0.06
- CADD 15.30
- PolyPhen-2 0.16
- SIFT 0.68
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available