K11N (p.Lys11Asn) variant of CDK12 (Cyclin-dependent kinase 12)
K11N (p.Lys11Asn) in CDK12 (Cyclin-dependent kinase 12) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data, published literature, and structural context.
K11N (p.Lys11Asn) variant details
- p.Lys11Asn
- gnomAD 17-39462104-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.4
- REVEL 0.28
- CADD 25.80
- PolyPhen-2 0.98
- SIFT 0.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available