K10R (p.Lys10Arg) variant of CDK12 (Cyclin-dependent kinase 12)
K10R (p.Lys10Arg) in CDK12 (Cyclin-dependent kinase 12) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
K10R (p.Lys10Arg) variant details
- p.Lys10Arg
- ExAC rs779054820
- gnomAD rs779054820
- Missense
- Variant Prioritization Score for Impact Estimate 0.428
- REVEL 0.27
- CADD 27.00
- PolyPhen-2 0.95
- SIFT 0.01
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available