K10E (p.Lys10Glu) variant of CDK12 (Cyclin-dependent kinase 12)
K10E (p.Lys10Glu) in CDK12 (Cyclin-dependent kinase 12) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data, published literature, and structural context.
K10E (p.Lys10Glu) variant details
- p.Lys10Glu
- gnomAD 17-39462099-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.48
- REVEL 0.36
- CADD 27.20
- PolyPhen-2 0.95
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available