G19R (p.Gly19Arg) variant of CDK12 (Cyclin-dependent kinase 12)
G19R (p.Gly19Arg) in CDK12 (Cyclin-dependent kinase 12) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, published literature, and structural context.
G19R (p.Gly19Arg) variant details
- p.Gly19Arg
- gnomAD 17-39462126-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.51
- REVEL 0.30
- CADD 28.90
- PolyPhen-2 1.00
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available