Y26C (p.Tyr26Cys) variant of CD40LG (CD40 ligand)
Y26C (p.Tyr26Cys) in CD40LG (CD40 ligand) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
Y26C (p.Tyr26Cys) variant details
- p.Tyr26Cys
- gnomAD rs2076094905
- Missense
- Variant Prioritization Score for Impact Estimate 0.226
- REVEL 0.14
- MetaLR 0.14
- MetaSVM -0.96
- CADD 19.20
- PolyPhen-2 0.00
- SIFT 0.22
- Most common in the African/African-American population (allele frequency 3.3e-05)
- Structural context available