L32F (p.Leu32Phe) variant of CD40LG (CD40 ligand)
L32F (p.Leu32Phe) in CD40LG (CD40 ligand) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
L32F (p.Leu32Phe) variant details
- p.Leu32Phe
- TOPMed rs1050576933
- gnomAD rs1050576933
- Missense
- Variant Prioritization Score for Impact Estimate 0.398
- REVEL 0.35
- MetaLR 0.33
- MetaSVM -0.54
- CADD 23.30
- PolyPhen-2 0.68
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 3.2e-05)
- Structural context available