G38W (p.Gly38Trp) variant of CD40LG (CD40 ligand)
G38W (p.Gly38Trp) in CD40LG (CD40 ligand) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data, published literature, and structural context.
G38W (p.Gly38Trp) variant details
- p.Gly38Trp
- gnomAD X-136648360-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.614
- REVEL 0.61
- MetaLR 0.45
- MetaSVM -0.06
- CADD 25.90
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- Literature evidence available