G21R (p.Gly21Arg) variant of CD3E (P07766)
G21R (p.Gly21Arg) in CD3E (P07766) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
G21R (p.Gly21Arg) variant details
- p.Gly21Arg
- rs774506155
- ExAC rs774506155
- gnomAD rs774506155
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.418
- REVEL 0.31
- MetaLR 0.31
- MetaSVM -0.69
- CADD 23.10
- PolyPhen-2 0.97
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:BURUSHO population (allele frequency 0.042)
- Structural context available