G46R (p.Gly46Arg) variant of CD3D (P04234)
G46R (p.Gly46Arg) in CD3D (P04234) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
G46R (p.Gly46Arg) variant details
- p.Gly46Arg
- gnomAD rs1444773153
- NCI-TCGA Cosmic COSV5267
- cosmic curated COSV52673
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.535
- REVEL 0.44
- CADD 23.40
- PolyPhen-2 0.87
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available