V65D (p.Val65Asp) variant of CD28 (P10747)
V65D (p.Val65Asp) in CD28 (P10747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data, published literature, and structural context.
V65D (p.Val65Asp) variant details
- p.Val65Asp
- gnomAD 2-203726774-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.701
- REVEL 0.83
- MetaLR 0.65
- MetaSVM 0.38
- CADD 24.50
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available