V63M (p.Val63Met) variant of CD28 (P10747)
V63M (p.Val63Met) in CD28 (P10747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
V63M (p.Val63Met) variant details
- p.Val63Met
- cosmic curated COSV60731
- TOPMed rs988481268
- gnomAD rs988481268
- Missense
- Variant Prioritization Score for Impact Estimate 0.361
- REVEL 0.34
- MetaLR 0.60
- MetaSVM -0.02
- CADD 17.00
- PolyPhen-2 0.97
- SIFT 0.05
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available