S73F (p.Ser73Phe) variant of CD28 (P10747)
S73F (p.Ser73Phe) in CD28 (P10747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, published literature, and structural context.
S73F (p.Ser73Phe) variant details
- p.Ser73Phe
- gnomAD 2-203726798-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.434
- REVEL 0.24
- MetaLR 0.27
- MetaSVM -0.58
- CADD 22.90
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available