S61T (p.Ser61Thr) variant of CD28 (P10747)
S61T (p.Ser61Thr) in CD28 (P10747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
S61T (p.Ser61Thr) variant details
- p.Ser61Thr
- gnomAD 2-203726762-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.295
- REVEL 0.17
- MetaLR 0.16
- MetaSVM -0.86
- CADD 23.90
- PolyPhen-2 0.79
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available