S26L (p.Ser26Leu) variant of CD28 (P10747)
S26L (p.Ser26Leu) in CD28 (P10747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
S26L (p.Ser26Leu) variant details
- p.Ser26Leu
- cosmic curated COSV60731
- Ensembl rs202067202
- Missense
- Variant Prioritization Score for Impact Estimate 0.325
- REVEL 0.24
- MetaLR 0.27
- MetaSVM -0.79
- CADD 11.40
- PolyPhen-2 0.03
- SIFT 0.42
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available