R3K (p.Arg3Lys) variant of CD28 (P10747)
R3K (p.Arg3Lys) in CD28 (P10747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
R3K (p.Arg3Lys) variant details
- p.Arg3Lys
- ExAC rs755944886
- gnomAD rs755944886
- Missense
- Variant Prioritization Score for Impact Estimate 0.293
- REVEL 0.23
- MetaLR 0.39
- MetaSVM -0.77
- CADD 15.20
- PolyPhen-2 0.05
- SIFT 0.77
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available