M28L (p.Met28Leu) variant of CD28 (P10747)
M28L (p.Met28Leu) in CD28 (P10747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
M28L (p.Met28Leu) variant details
- p.Met28Leu
- ExAC rs771698017
- TOPMed rs771698017
- gnomAD rs771698017
- Missense
- Variant Prioritization Score for Impact Estimate 0.123
- REVEL 0.04
- MetaLR 0.19
- MetaSVM -0.95
- CADD 2.45
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available