L46F (p.Leu46Phe) variant of CD28 (P10747)
L46F (p.Leu46Phe) in CD28 (P10747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
L46F (p.Leu46Phe) variant details
- p.Leu46Phe
- gnomAD 2-203726716-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.297
- REVEL 0.15
- MetaLR 0.32
- MetaSVM -0.89
- CADD 19.00
- PolyPhen-2 0.02
- SIFT 0.18
- Population evidence available
- Structural context available
- Literature evidence available