L29I (p.Leu29Ile) variant of CD28 (P10747)
L29I (p.Leu29Ile) in CD28 (P10747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
L29I (p.Leu29Ile) variant details
- p.Leu29Ile
- ExAC rs773299801
- TOPMed rs773299801
- gnomAD rs773299801
- Missense
- Variant Prioritization Score for Impact Estimate 0.474
- REVEL 0.41
- MetaLR 0.61
- MetaSVM 0.17
- CADD 22.20
- PolyPhen-2 0.85
- SIFT 0.07
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available