K57N (p.Lys57Asn) variant of CD28 (P10747)
K57N (p.Lys57Asn) in CD28 (P10747) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
K57N (p.Lys57Asn) variant details
- p.Lys57Asn
- NCI-TCGA Cosmic COSV6073
- cosmic curated COSV60731
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.396
- REVEL 0.49
- MetaLR 0.49
- MetaSVM -0.15
- CADD 23.60
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available