I14T (p.Ile14Thr) variant of CD28 (P10747)
I14T (p.Ile14Thr) in CD28 (P10747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, published literature, and structural context.
I14T (p.Ile14Thr) variant details
- p.Ile14Thr
- gnomAD 2-203706737-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.375
- REVEL 0.38
- MetaLR 0.48
- MetaSVM -0.66
- CADD 15.70
- PolyPhen-2 0.01
- SIFT 0.09
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available