Y32D (p.Tyr32Asp) variant of CD274 (Programmed cell death 1 ligand 1)
Y32D (p.Tyr32Asp) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
Y32D (p.Tyr32Asp) variant details
- p.Tyr32Asp
- ExAC rs747317241
- gnomAD rs747317241
- Missense
- Variant Prioritization Score for Impact Estimate 0.393
- REVEL 0.28
- AlphaMissense 0.52
- MetaLR 0.34
- MetaSVM -0.52
- CADD 22.80
- PolyPhen-2 0.98
- Most common in the Middle Eastern population (allele frequency 0.0032)
- Structural context available