Y32C (p.Tyr32Cys) variant of CD274 (Programmed cell death 1 ligand 1)
Y32C (p.Tyr32Cys) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
Y32C (p.Tyr32Cys) variant details
- p.Tyr32Cys
- Ensembl rs2131211170
- Missense
- Variant Prioritization Score for Impact Estimate 0.337
- REVEL 0.27
- AlphaMissense 0.47
- MetaLR 0.38
- MetaSVM -0.31
- CADD 23.80
- PolyPhen-2 1.00
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available