Y28F (p.Tyr28Phe) variant of CD274 (Programmed cell death 1 ligand 1)
Y28F (p.Tyr28Phe) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
Y28F (p.Tyr28Phe) variant details
- p.Tyr28Phe
- TOPMed rs1299227177
- gnomAD rs1299227177
- Missense
- Variant Prioritization Score for Impact Estimate 0.248
- REVEL 0.09
- AlphaMissense 0.12
- MetaLR 0.02
- MetaSVM -1.01
- CADD 24.60
- PolyPhen-2 0.87
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available