V6L (p.Val6Leu) variant of CD274 (Programmed cell death 1 ligand 1)
V6L (p.Val6Leu) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
V6L (p.Val6Leu) variant details
- p.Val6Leu
- TOPMed rs1586762927
- gnomAD rs1586762927
- Missense
- Variant Prioritization Score for Impact Estimate 0.107
- REVEL 0.06
- AlphaMissense 0.14
- MetaLR 0.08
- MetaSVM -0.98
- CADD 0.22
- PolyPhen-2 0.03
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available