V6F (p.Val6Phe) variant of CD274 (Programmed cell death 1 ligand 1)
V6F (p.Val6Phe) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
V6F (p.Val6Phe) variant details
- p.Val6Phe
- TOPMed rs1586762927
- gnomAD rs1586762927
- Missense
- Variant Prioritization Score for Impact Estimate 0.16
- REVEL 0.12
- AlphaMissense 0.09
- MetaLR 0.12
- MetaSVM -0.99
- CADD 8.35
- PolyPhen-2 0.52
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available