V23L (p.Val23Leu) variant of CD274 (Programmed cell death 1 ligand 1)
V23L (p.Val23Leu) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
V23L (p.Val23Leu) variant details
- p.Val23Leu
- gnomAD rs1485681345
- Missense
- Variant Prioritization Score for Impact Estimate 0.411
- REVEL 0.32
- AlphaMissense 0.46
- MetaLR 0.30
- MetaSVM -0.52
- CADD 23.10
- PolyPhen-2 0.72
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available