V21I (p.Val21Ile) variant of CD274 (Programmed cell death 1 ligand 1)
V21I (p.Val21Ile) in CD274 (Programmed cell death 1 ligand 1) is a missense change. Clinical records from ClinVar and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
V21I (p.Val21Ile) variant details
- p.Val21Ile
- ESP rs370800260
- ExAC rs370800260
- TOPMed rs370800260
- gnomAD rs370800260
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.139
- REVEL 0.08
- AlphaMissense 0.08
- MetaLR 0.18
- MetaSVM -1.02
- CADD 5.53
- PolyPhen-2 0.05
- ClinVar: Likely benign (not specified)
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available