T22M (p.Thr22Met) variant of CD274 (Programmed cell death 1 ligand 1)
T22M (p.Thr22Met) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
T22M (p.Thr22Met) variant details
- p.Thr22Met
- ESP rs143235887
- ExAC rs143235887
- TOPMed rs143235887
- gnomAD rs143235887
- Missense
- Variant Prioritization Score for Impact Estimate 0.368
- REVEL 0.29
- AlphaMissense 0.10
- MetaLR 0.38
- MetaSVM -0.39
- CADD 23.60
- PolyPhen-2 1.00
- Most common in the REMAINING population (allele frequency 0.00022)
- Structural context available