T20S (p.Thr20Ser) variant of CD274 (Programmed cell death 1 ligand 1)
T20S (p.Thr20Ser) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
T20S (p.Thr20Ser) variant details
- p.Thr20Ser
- TOPMed rs937227717
- Missense
- Variant Prioritization Score for Impact Estimate 0.261
- REVEL 0.12
- AlphaMissense 0.20
- MetaLR 0.15
- MetaSVM -0.97
- CADD 20.60
- PolyPhen-2 0.03
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available