R2S (p.Arg2Ser) variant of CD274 (Programmed cell death 1 ligand 1)
R2S (p.Arg2Ser) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
R2S (p.Arg2Ser) variant details
- p.Arg2Ser
- Ensembl rs2131208624
- Missense
- Variant Prioritization Score for Impact Estimate 0.363
- REVEL 0.10
- AlphaMissense 0.42
- MetaLR 0.11
- MetaSVM -0.97
- CADD 23.60
- PolyPhen-2 0.70
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available