P24S (p.Pro24Ser) variant of CD274 (Programmed cell death 1 ligand 1)
P24S (p.Pro24Ser) in CD274 (Programmed cell death 1 ligand 1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
P24S (p.Pro24Ser) variant details
- p.Pro24Ser
- rs766519356
- NCI-TCGA Cosmic COSV1010
- ExAC rs766519356
- gnomAD rs766519356
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.195
- REVEL 0.12
- AlphaMissense 0.17
- MetaLR 0.15
- MetaSVM -1.03
- CADD 9.61
- PolyPhen-2 0.40
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 5.1e-05)
- Structural context available