L27I (p.Leu27Ile) variant of CD274 (Programmed cell death 1 ligand 1)
L27I (p.Leu27Ile) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
L27I (p.Leu27Ile) variant details
- p.Leu27Ile
- TOPMed rs1383983432
- gnomAD rs1383983432
- Missense
- Variant Prioritization Score for Impact Estimate 0.233
- REVEL 0.14
- AlphaMissense 0.07
- MetaLR 0.36
- MetaSVM -0.63
- CADD 18.70
- PolyPhen-2 0.14
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available