K25R (p.Lys25Arg) variant of CD274 (Programmed cell death 1 ligand 1)
K25R (p.Lys25Arg) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
K25R (p.Lys25Arg) variant details
- p.Lys25Arg
- ExAC rs754087767
- TOPMed rs754087767
- gnomAD rs754087767
- Missense
- Variant Prioritization Score for Impact Estimate 0.304
- REVEL 0.18
- AlphaMissense 0.08
- MetaLR 0.33
- MetaSVM -0.45
- CADD 24.90
- PolyPhen-2 0.90
- Most common in the HGDP:PALESTINIAN population (allele frequency 0.013)
- Structural context available