I8V (p.Ile8Val) variant of CD274 (Programmed cell death 1 ligand 1)
I8V (p.Ile8Val) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
I8V (p.Ile8Val) variant details
- p.Ile8Val
- TOPMed rs981554963
- Missense
- Variant Prioritization Score for Impact Estimate 0.0857
- REVEL 0.02
- AlphaMissense 0.09
- MetaLR 0.07
- MetaSVM -0.99
- CADD 1.15
- PolyPhen-2 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available