I8T (p.Ile8Thr) variant of CD274 (Programmed cell death 1 ligand 1)
I8T (p.Ile8Thr) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data, published literature, and structural context.
I8T (p.Ile8Thr) variant details
- p.Ile8Thr
- gnomAD 9-5456136-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.0834
- REVEL 0.02
- AlphaMissense 0.09
- MetaLR 0.05
- MetaSVM -1.03
- CADD 1.85
- PolyPhen-2 0.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available