I8M (p.Ile8Met) variant of CD274 (Programmed cell death 1 ligand 1)
I8M (p.Ile8Met) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, published literature, and structural context.
I8M (p.Ile8Met) variant details
- p.Ile8Met
- gnomAD 9-5456137-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.153
- REVEL 0.03
- AlphaMissense 0.14
- MetaLR 0.09
- MetaSVM -1.01
- CADD 13.70
- PolyPhen-2 0.22
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- Literature evidence available