I8K (p.Ile8Lys) variant of CD274 (Programmed cell death 1 ligand 1)
I8K (p.Ile8Lys) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data, published literature, and structural context.
I8K (p.Ile8Lys) variant details
- p.Ile8Lys
- gnomAD 9-5456136-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.177
- REVEL 0.15
- AlphaMissense 0.37
- MetaLR 0.09
- MetaSVM -1.00
- CADD 11.90
- PolyPhen-2 0.43
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available