I3V (p.Ile3Val) variant of CD274 (Programmed cell death 1 ligand 1)
I3V (p.Ile3Val) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
I3V (p.Ile3Val) variant details
- p.Ile3Val
- gnomAD 9-5456120-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.212
- REVEL 0.08
- AlphaMissense 0.12
- MetaLR 0.09
- MetaSVM -0.97
- CADD 22.10
- PolyPhen-2 0.01
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available