I3M (p.Ile3Met) variant of CD274 (Programmed cell death 1 ligand 1)
I3M (p.Ile3Met) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
I3M (p.Ile3Met) variant details
- p.Ile3Met
- gnomAD rs1433541247
- Missense
- Variant Prioritization Score for Impact Estimate 0.304
- REVEL 0.03
- AlphaMissense 0.15
- MetaLR 0.07
- MetaSVM -1.03
- CADD 15.80
- PolyPhen-2 0.17
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available