F4Y (p.Phe4Tyr) variant of CD274 (Programmed cell death 1 ligand 1)
F4Y (p.Phe4Tyr) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
F4Y (p.Phe4Tyr) variant details
- p.Phe4Tyr
- ExAC rs748476315
- TOPMed rs748476315
- gnomAD rs748476315
- Missense
- Variant Prioritization Score for Impact Estimate 0.0951
- REVEL 0.02
- AlphaMissense 0.19
- MetaLR 0.07
- MetaSVM -1.01
- CADD 5.72
- PolyPhen-2 0.00
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available