F4C (p.Phe4Cys) variant of CD274 (Programmed cell death 1 ligand 1)
F4C (p.Phe4Cys) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
F4C (p.Phe4Cys) variant details
- p.Phe4Cys
- ExAC rs748476315
- TOPMed rs748476315
- gnomAD rs748476315
- Missense
- Variant Prioritization Score for Impact Estimate 0.0992
- REVEL 0.02
- AlphaMissense 0.22
- MetaLR 0.07
- MetaSVM -1.01
- CADD 8.24
- PolyPhen-2 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available