A5T (p.Ala5Thr) variant of CD274 (Programmed cell death 1 ligand 1)
A5T (p.Ala5Thr) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data, published literature, and structural context.
A5T (p.Ala5Thr) variant details
- p.Ala5Thr
- gnomAD 9-5456126-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.108
- REVEL 0.02
- AlphaMissense 0.12
- MetaLR 0.08
- MetaSVM -0.96
- CADD 4.51
- PolyPhen-2 0.22
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available