A18P (p.Ala18Pro) variant of CD274 (Programmed cell death 1 ligand 1)
A18P (p.Ala18Pro) in CD274 (Programmed cell death 1 ligand 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
A18P (p.Ala18Pro) variant details
- p.Ala18Pro
- TOPMed rs1243212672
- gnomAD rs1243212672
- Missense
- Variant Prioritization Score for Impact Estimate 0.467
- REVEL 0.21
- AlphaMissense 0.39
- MetaLR 0.38
- MetaSVM -0.27
- CADD 35.00
- PolyPhen-2 0.99
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available