Y84H (p.Tyr84His) variant of CD2 (T-cell surface antigen CD2)
Y84H (p.Tyr84His) in CD2 (T-cell surface antigen CD2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
Y84H (p.Tyr84His) variant details
- p.Tyr84His
- rs1358000886
- NCI-TCGA Cosmic COSV6564
- cosmic curated COSV65643
- gnomAD rs1358000886
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.308
- REVEL 0.18
- MetaLR 0.08
- MetaSVM -1.09
- CADD 23.20
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available