K85E (p.Lys85Glu) variant of CD2 (T-cell surface antigen CD2)
K85E (p.Lys85Glu) in CD2 (T-cell surface antigen CD2) is a missense change. Clinical records from ClinVar and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data and structural context.
K85E (p.Lys85Glu) variant details
- p.Lys85Glu
- TOPMed rs970858006
- gnomAD rs970858006
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.0713
- REVEL 0.02
- MetaLR 0.02
- MetaSVM -1.08
- CADD 0.03
- PolyPhen-2 0.00
- SIFT 1.00
- ClinVar: Likely benign (not specified)
- UniProt: Likely benign
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available